Adaptation to drought is critical for many species, especially those that thrive in the Mediterranean area. Knowing the processes by which a species can develop a rapid adaptation to drought can be essential if we want to maintain its survival. In the case of species of agricultural interest, this is enhanced by the need to ensure minimum production levels that make the species profitable. In the adaptation process, there are several agents and factors that intervene, although they have been studied in isolation. DACWIRE is framed within the study of local adaptation, addressing the complex interaction between genotypes, phenotypes and the environment. The main goal of this research project is to find the genetic determinants of plant adaptation to drought stress, and to identify valuable genetic variation for adaptation to climate change. The project will combine approaches from population genomics, quantitative genetics, microbiology and ecophysiology with a common garden approach to yield a very efficient, thorough and integrative study of drought adaptation. Studies will be developed on blue lupin (Lupinus angustifolius L.), a legume with economic value. The diploid genome organization, autogamous reproduction and short generation time make it ideal for study evolutionary processes. Obtained results will identify genetic variation underlying relevant traits for climatic adaptation, emphasizing gene networks associated with growth, flowering phenology and drought stress. DACWIRE provides an innovative contribution to the objective of improving scientific knowledge on climate change mitigation and adaptation options for cultivated and wild species pursued in the priority number 6 “Food, Bioeconomy, Natural Resources and Environment” of the Spanish Plan for Scientific, Technical and Innovation Research (2021-2023) and some of the Sustainable Development Goals of the United Nations.